Heitor Moreno Jr.

Principal Investigator
Studies the role of gene polymorphisms on hemodynamic parameter and vascular stiffness in obese resistant hypertensive patients.

School of Medical Sciences – University of Campinas

Laboratório de Farmacologia Cardiovascular

Heitor Moreno’s laboratory focuses on Resistant Arterial Hypertension (RAH), studying the physiology of the disease and shedding light on the associated health problems. The researched areas include:

  • Lesions in organs targeted in RAH and mild to moderate (AH) hypertensive patients: endothelial function assessment, arterial rigidity, cardiac hypertrophy and renal function by microalbuminuria;
  • Clinical conditions associated with RAH: myocardial ischemia, left ventricular diastolic function, obesity and type 2 diabetes;
  • Hormonal and inflammatory profile in AH and RAH: determination of aldosterone, cortisol, insulin, adipokines, interleukins, and extracellular matrix metalloproteinases (EMMs) levels in plasma;
  • Genetic polymorphisms in AH and RAH: genotyping of hypertensive individuals for the most relevant genetic polymorphisms (genes: mineralocorticoid receptor, aldosterone synthase enzyme, leptin, adiponectin, MMP-2 and -9);
  • Intervention studies with phosphodiesterase-5 (IPDE-5: sildenafil and tafalafil) inhibitors in LV diastolic dysfunction.

main discoveries

  • Therapeutic use of IPDE-5 in the treatment of LV diastolic dysfunction in RAH;
  • Spironolactone as an aid in the treatment of RAH;
  • Discovery of the true prevalence of myocardial ischemia in RAH;
  • Clinical and hormonal differences between resistant hypertensive/hypertensive/normotensive patients;
  • Association of aldosterone synthase and adiponectin genetic polymorphisms in RAH;
  • Pharmacotherapeutic follow-up increases adherence to treatment in RAH.

main articles

  • Role of Transcytolemmal Water-Exchange in Magnetic Resonance Measurements of Diffuse Myocardial Fibrosis in Hypertensive Heart Disease
  • Infliximab prevents increased systolic blood pressure and upregulates the AKT/eNOS pathway in the aorta of spontaneously hypertensive rats
  • Phenotypic Characteristics of Resistant Hypertension in the Brazilian Population
  • Quantification of Cardiomyocyte Hypertrophy by Cardiac Magnetic Resonance
  • Renin Angiotensin System Blockage Associates with Insertion/Deletion Polymorphism of Angiotensin-Converting Enzyme in Patients with Hypertensive Emergency
  • Modulation of aldosterone levels by 344 C/T CYP11B2 polymorphism and spironolactone use in resistant hypertension
  • Tadalafil-induced improvement in left ventricular diastolic function in resistant hypertension
  • Acute cardiac and hemodynamic effects of sildenafil on resistant hypertension
To contact Heitor Moreno Jr.'s lab use the following information:
Laboratório de Farmacologia Cardiovascular
FCM10 - Departamento de Farmacologia
Rua Alexander Fleming, 105 - Cidade Universitária Zeferino Vaz
Campinas - SP, 13084-971
+55 19 3521-9538 / +55 19 3521-9539