Jose Donato Jr

Principal Investigator
Neuroendocrine control of energy balance and glucose homeostasis. Keywords: Hypothalamus; leptin; growing hormone; food intake; obesity, diabetes mellitus.
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Institute of Biomedical Sciences – University of São Paulo

Laboratory of Functional Neuroanatomy – Department of Physiology and Biophysics

The research developed in our laboratory aims to understand how neural circuits that regulate food intake, body weight and glycemic control are affected by hormonal variations. In this sense, we study the action and function of the hormones leptin, prolactin, GH, insulin and estradiol on these neural circuits. This central hormonal interaction may be key in alterations in food intake, control of body weight, adiposity, and glycemia observed in metabolic disorders such as obesity and type 2 diabetes mellitus.

TEAM

TECHNICAL STAFF

  • Ana Maria Campos

RESEARCH FELLOW

  • Isadora Clivatti Furigo

phd

  • Fernanda Machado Chaves

MASTER

  • Gabriel Orefice de Souza
  • Willian Oliveira dos Santos

MAIN ARTICLES

1) Wasinski F, Pedroso JAB, Dos Santos WO, Furigo IC, Garcia-Galiano D, Elias CF, List EO, Kopchick JJ, Szawka RE, Donato J Jr. Tyrosine Hydroxylase Neurons Regulate Growth Hormone Secretion via Short-Loop Negative Feedback. Journal of Neuroscience (FI: 5,7) 40(22):4309-4322, 2020.

2) Furigo IC, Teixeira PDS, de Souza GO, Couto GCL, Romero GG, Perelló M, Frazão R, Elias LL, Metzger M, List EO, Kopchick JJ, Donato J Jr. Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons. Nature Communications (FI: 12,1) 10(1):662, 2019. (Citações: 18)

3) Furigo IC, de Souza GO, Teixeira PDS, Guadagnini D, Frazão R, List EO, Kopchick JJ, Prada PO, Donato J Jr. Growth hormone enhances the recovery of hypoglycemia via ventromedial hypothalamic neurons. FASEB Journal (FI: 5,0) 33(11):11909-11924, 2019. (Citações: 5)

4) Ramos-Lobo AM, Teixeira PD, Furigo IC, Melo HM, de M Lyra E Silva N, De Felice FG, Donato J Jr. Long-term consequences of the absence of leptin signaling in early life. Elife (FI: 7,1) e40970, 2019. (Citações: 5)

5) Zampieri TT, Ramos-Lobo AM, Furigo IC, Pedroso JAB, Buonfiglio DC, Donato J Jr. SOCS3 deficiency in leptin receptor-expressing cells mitigates the development of pregnancy-induced metabolic changes. Molecular Metabolism (FI: 6,4) 4:237-245, 2015. (Citações: 36)

6) Pedroso JA, Buonfiglio DC, Cardinali LI, Furigo IC, Ramos-Lobo AM, Tirapegui J, Elias CF, Donato J Jr. Inactivation of SOCS3 in leptin receptor-expressing cells protects mice from diet-induced insulin resistance but does not prevent obesity. Molecular Metabolism (FI: 6,4) 3(6):608-18, 2014. (Citações: 66)

7) Kim KW, Donato J Jr, Berglund ED, Choi YH, Kohno D, Elias CF, Depinho RA, Elmquist JK. FOXO1 in the ventromedial hypothalamus regulates energy balance. Journal of Clinical Investigation (FI: 11,9) 122(7):2578-89, 2012. (Citações: 101)

8) Berglund ED, Vianna CR, Donato J Jr, Kim MH, Chuang JC, Lee CE, Lauzon DA, Lin P, Brule LJ, Scott MM, Coppari R, Elmquist JK. Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice. Journal of Clinical Investigation (FI: 11,9) 122(3):1000-9, 2012. (Citações: 274)

9) Donato J Jr, Cravo RM, Frazão R, Gautron L, Scott MM, Lachey J, Castro IA, Margatho LO, Lee S, Lee C, Richardson JA, Friedman J, Chua S Jr, Coppari R, Zigman JM, Elmquist JK, Elias CF. Leptin’s effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons. Journal of Clinical Investigation (FI: 11,9) 121(1):355-68, 2011. (Citações: 281)

10) Lam DD, Leinninger GM, Louis GW, Garfield AS, Marston OJ, Leshan RL, Scheller EL, Christensen L, Donato J Jr, Xia J, Evans ML, Elias C, Dalley JW, Burdakov DI, Myers MG Jr, Heisler LK. Leptin does not directly affect CNS serotonin neurons to influence appetite. Cell Metabolism (FI: 21,6) 13(5):584-91, 2011. (Citações: 55)

To contact Jose Donato Jr's lab use the following information:
Av. Prof. Lineu Prestes, 1524 - Sala 234
Cidade Universitaria - São Paulo, SP - Brasil
CEP: 05508-000

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E-mail: [email protected]
Telefone: (11) 3091-7216