Marcio Alberto Torsoni
Faculty of Applied Sciences – State University of Campinas
The laboratory has interest in the investigation of the associated mechanism to damage to body homeostasis (inflammatory and anti-inflammatory response, glucose homeostase, energy expenditure and food intake) in models of metabolic programming and diet-induce obesity. The laboratory has interest in molecular mechanisms associated with autophagy, proteostasis, apoptosis, DNA methylation, microRNA and lipid metabolism. Fetal programming and consumption of a high-fat diet have important effects on energy homeostasis and inflammatory response. The cholinergic system participates of the control of inflammatory response and neuronal excitation. Damage to the cholinergic system has profound impact on hypothalamic activity, potency of the inflammatory response, prevention of cell damage and hormonal signaling. We investigated which molecular mechanisms are involved in the damage to the cholinergic system as well the effects on the control of body homeostasis.
- Lais Simino
- Priscila Karla Lopes
- Alana Veras
- Suleyma de Oliveira Costa
- Wenicios Ferreira
- Camila Libardi do Amaral
- Caroline Lobo Costa
- Isis Martins
- Larissa Bruzasco
- Gabriela Claudiano
- Ana Beatriz Lopes
- SOUZA ACP, SOUZA CM AMARAL, CL, LEMES SF, SANTUCCI LF, MILANSKI M, TORSONI AS TORSONI MA. Short-Term High-Fat Diet Consumption Reduces Hypothalamic Expression of the Nicotinic Acetylcholine Receptor α7 Subunit (α7nAChR) and Affects the Anti-inflammatory Response in a Mouse Model of Sepsis. Immunol. doi.org/10.3389/fimmu.2019.00565, 2019.
- SOUZA CM; AMARAL, CL; SOUZA, SO; SOUZA, ACP; MARTINS, ICA; CONTIERI, LS; MILANSKI, M; TORSONI, AS; IGNACIO-SOUZA, LM; TORSONI, MA. JAK2/STAT3 Pathway is Required for α7nAChR-Dependent Expression of POMC and AGRP Neuropeptides in Male Mice. Cell Physiol Biochem 53:701-712. (2019) DOI: 10.33594/000000166.
- LEMES SF, DE SOUZA ACP, PAYOLLA TB, VERSUTTI MD, DE FÁTIMA DA SILVA RAMALHO A, MENDES-DA-SILVA C, SOUZA CM, MILANSKI M, TORSONI AS, TORSONI MA. Maternal Consumption of High-fat Diet in Mice Alters Hypothalamic Notch Pathway, NPY Cell Population and Food Intake in Offspring. 371:1-15, 2018.
- MIYAMOTO JE, FERRAZ ACG, PORTOVEDO M, REGINATO A, STAHL MA, IGNACIO-SOUZA LM, CHAN KL, TORSONI AS, TORSONI MA, RIBEIRO APB, MILANSKI M. Interesterified soybean oil promotes weight gain, impaired glucose tolerance and increased liver cellular stress markers. J Nutr Biochem. 59:153-159, 2018.
- TORSONI MA, BORGES BC, COTE JL, ALLEN SJ, MAHANY E, GARCIA-GALIANO D, ELIAS CF. AMPKα2 in Kiss1 neurons is required for the reproductive adaptations to acute metabolic challenges in adult female mice. 157(12):4803-4816, 2016.
- PAYOLLA TB, LEMES SF, DE FANTE T, REGINATO A, MENDES DA SILVA C, DE OLIVEIRA MICHELETTI T, RODRIGUES HG, TORSONI AS, MILANSKI M, TORSONI MA. High-fat diet during pregnancy and lactation impairs the cholinergic anti-inflammatory pathway in the liver and white adipose tissue of mouse offspring. Mol Cell Endocrinol. 422:192-202. 2016.
- MENDES-DA-SILVA C, LEMES SF, BALIANI TD, VERSUTTI MD, TORSONI MA. Increased expression of Hes5 protein in Notch signaling pathway in the hippocampus of mice offspring of dams fed a high-fat diet during pregnancy and suckling. Int J Dev Neurosci. 40:35-42, 2015.
- MELO AM, BENATTI RO, IGNACIO-SOUZA LM, OKINO C, TORSONI AS, MILANSKI M, VELLOSO LA, TORSONI MA. Hypothalamic endoplasmic reticulum stress and insulin resistance in offspring of mice dams fed high-fat diet during pregnancy and lactation. Metabolism 63(5): 682-92, 2014.
- SANTOS, G.A., MOURA, R.F., VITORINO, D.C., ROMAN, E.A.F.R., TORSONI, A.S., VELLOSO, L.A., TORSONI, M.A. Hypothalamic AMPK activation blocks lipopolysaccharide inhibition of glucose production in mice liver. Molecular and Cellular Endocrinology, 14, p.156 – 165, 2013.
- ASHINO NG, SAITO KN, SOUZA FD, NAKUTZ FS, ROMAN EA, VELLOSO LA, TORSONI AS, TORSONI MA. Maternal high-fat feeding through pregnancy and lactation predisposes mouse offspring to molecular insulin resistance and fatty liver. J Nutr Biochem. 22: 456-501, 2012.
Rua Pedro Zaccaria, 1300-Jd Santa Luiza
Prédio dos Laboratórios I
Email: [email protected]