Eduardo Rochete Ropelle

Pesquisador Associado
Trabalha na área de biologia molecular do exercício, atuando nos seguintes temas: exercício, obesidade, diabetes e envelhecimento.
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Faculdade de Ciências Aplicadas – Universidade Estadual de Campinas

Laboratório de Biologia Molecular do Exercício – LaBMEx

O laboratório investiga o efeito do exercício físico sobre a sensibilidade à insulina e sobre o metabolismo mitocondrial em modelos experimentais de obesidade e envelhecimento.

EQUIPE

Doutorado

Mestrado

  • Barbara M. Crisol
  • André V. Cordeiro

Iniciação Científica

  • Renata Rosseto
  • Rafael Bricola
  • Fernanda Chaparro

PRINCIPAIS ARTIGOS

1 Silva VRR, Micheletti TO, Katashima CK, Lenhare L, Morari J, Moura-Assis A, Lima-Junior JC, Camargo JA, Passos GR, Gaspar RS, Velloso LA, Saad MJ, Silva ASR, Moura LP, Cintra DE, Pauli JR, Ropelle ER. Exercise activates hypothalamic S1PR1/STAT3 axis through the central action of interleukin-6 in mice. J Cell Physiol. 2018.

2 Lenhare L, Crisol BM, Silva VRR, Katashima CK, Cordeiro AV, Pereira KD, Luchessi AD, da Silva ASR, Cintra DE, Moura LP, Pauli JR, Ropelle ER. Physical exercise increases Sestrin 2 protein levels and induces autophagy in the skeletal muscle of old mice.
Exp Gerontol. 2017.

3 Silva VR, Katashima CK, Bueno Silva CG, Lenhare L, Micheletti TO, Camargo RL, Ghezzi AC, Camargo JA, Assis AM, Tobar N, Morari J, Razolli DS, Moura LP, Pauli JR, Cintra DE, Velloso LA, Saad MJ, Ropelle ER. Hypothalamic S1P/S1PR1 axis controls energy homeostasis in Middle-Aged Rodents: the reversal effects of physical exercise. Aging (Albany NY). 2016 Dec 26;9(1):142-155.

4 Zhang H, Ryu D, Wu Y, Gariani K, Wang X, Luan P, D’Amico D, Ropelle ER, Lutolf MP,Aebersold R, Schoonjans K, Menzies KJ, Auwerx J. NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice.
Science. 2016 Jun 17;352(6292):1436-43.

5 Ryu D, Zhang H, Ropelle ER, Sorrentino V, Mázala DA, Mouchiroud L, Marshall PL, Campbell MD, Ali AS, Knowels GM, Bellemin S, Iyer SR, Wang X, Gariani K, Sauve AA, Cantó C, Conley KE, Walter L, Lovering RM, Chin ER, Jasmin BJ, Marcinek DJ, Menzies KJ, Auwerx J. NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation. Sci Transl Med. 2016 Oct 19;8(361):361ra139.

6 Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, Kim B, Park YK, Piersigilli A, Pham TX, Yang Y, Ku CS, Koo SI, Fomitchova A, Cantó C, Schoonjans K, Sauve AA, Lee JY, Auwerx J. Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice. Hepatology. 2016 Apr;63(4):1190-204. doi: 10.1002/hep.28245. (Fator de impacto- 13.24)

7 van de Weijer T, Phielix E, Bilet L, Williams EG, Ropelle ER, Bierwagen A, Livingstone R, Nowotny P, Sparks LM, Paglialunga S, Szendroedi J, Havekes B, Moullan N, Pirinen E, Hwang JH, Schrauwen- Hinderling VB, Hesselink MK, Auwerx J, Roden M, Schrauwen P. Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans. Diabetes. 2015 Apr;64(4):1193-201. doi: 10.2337/db14-0667.

8 Silva VR, Micheletti TO, Pimentel GD, Katashima CK, Lenhare L, Morari J, Mendes MC, Razolli DS, Rocha GZ, de Souza CT, Ryu D, Prada PO, Velloso LA, Carvalheira JB, Pauli JR, Cintra DE, Ropelle ER. Hypothalamic S1P/S1PR1 axis controls energy homeostasis.
Nat Commun. 2014 Sep 25;5:4859. doi: 10.1038/ncomms5859.

9 Souza Pauli LS, Ropelle EC, de Souza CT, Cintra DE, da Silva AS, de Almeida Rodrigues B, de Moura LP, Marinho R, de Oliveira V, Katashima CK, Pauli JR, Ropelle ER.
Exercise training decreases mitogen-activated protein kinase phosphatase-3 expression and suppresses hepatic gluconeogenesis in obese mice. bJ Physiol. 2014 Mar 15;592(6):1325-40.

10 Ropelle ER, Flores, MB, Cintra DE, Rocha GZ, Pauli JR, Morari J, de Souza CT, Moraes J C, Prada PO, Guadagnini D, Marin M, Oliveira AG, Augusto TM, Carvalho H F, Velloso A, Saad MJ, Carvalheira JB. IL-6 and IL-10 Anti-Inflammatory Activity Links Exercise to Hypothalamic Insulin and Leptin Sensitivity through IKK and ER Stress Inhibition. PLoS Biology. v.8, p.e1000465 – , 2010.

 

 

Para entrar em contato com Eduardo Rochete Ropelle e seu laboratório utilize as informações a seguir:
Laboratório de Biologia Molecular do Exercício - LaBMEx
Faculdade de Ciências Aplicadas (Prédio Laboratórios 2)
R. Pedro Zaccaria, 1300
Limeira - São Paulo, CEP-13484-350
+55 19 3701-6689