Marcelo Alves da Silva Mori

Pesquisador Principal
Atua na área de biologia do envelhecimento e sua interface com o metabolismo energético. Palavras-chave: Envelhecimento, miRNAs, Tecido Adiposo, Diabetes, Obesidade

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Institute of Biology  – University of Campinas

 

Laboratório de Biologia do Envelhecimento (LaBE)

The main purpose of our lab is to identify and characterize molecular mechanisms involved in the aging process and in response to dietary interventions. We pay particular interest to understand how metabolism contributes to the genesis of age-related diseases like type 2 diabetes, cardiovascular diseases, and neurodegenerative diseases. We focus on the fat tissue – an important site of metabolic integration in multicellular organisms – and ask ourselves how this tissue responds to changes in energy balance and signals to other tissues to inform them about these changes. If not adjusted, this mechanism leads to several chronic diseases, especially in middle aged and elderly individuals. We identified that this control is at least in part exerted by changes in microRNA biogenesis in adipose tissue. When regulated, this process affects animal susceptibility to metabolic stress and influences lifespan.

TEAM

Technical staff

  • Elzira Elisabeth Saviani

Research Fellow

  • Danilo Lopes Ferrucci
  • Felippe Mousovich Neto
  • Juliano Quintella Dantas Rodrigues
  • Narayana P. B. Fazolini

pHD

  • Andrea Livia Rocha
  • Carlos Alberto Vergani Junior
  • Deisi Lilian Braga
  • Gabriel Palermo Ruiz
  • Gerson Profeta de Souza
  • Henrique Camara
  • Mehmet Dinçer İnan
  • Raissa Guimarães Ludwig
  • Silas Pinto da Silva
  • Thiago Leite Knittel
  • Carolina Mie Kawagosi Onodera

Master

  • Guilherme Tonon
  • Matheus Pedroni Negrão
  • Sweta Sarmah
  • Willian Goulart Salgueiro

Scientific Initiation

  • Rhaissa Godoi

scholarship SAE (Student Support Service)

  • Alexandre de Souza Santos
  • Jéssica Rodrigues de Andrade
  • Raul Gobato da Costa

main discoveries

The lab has described how the miRNA biogenesis pathway can be altered in the adipose tissue with aging, obesity and lipodystrophy, and how such changes in miRNA expression contribute to the onset of chronic diseases. We have also contributed to the discovery of the adipose tissue as one of the most important sources of circulating miRNAs acting to mediate intertissue communication.

main articles

  • De-Souza EA, Camara H, Salgueiro WG, Moro RP, Knittel TL, Tonon G, Pinto S, Pinca, AP, Antebi A, Pasquinelli A, Massirer KB, Mori MA. RNA Interference May Result in Unexpected Phenotypes in Caenorhabditis elegans. Nucleic Acid Research. 2019 Mar 6. pii: gkz154. Citations: 1
  • Pinto S, Sato VN, De-Souza EA, Ferraz RC, Camara H, Pinca APF, Mazzotti DR, Lovci MT, Tonon G, Lopes-Ramos CM, Parmigiani RB, Wurtele M, Massirer KB, Mori MA. Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis. Redox Biol. 2018: 18:84-92. Citações em MyCitations: 6
  • Thomou T, Mori MA, Dreyfuss JM, Konishi M, Sakagushi M, Wolfrum C, Rao TN, Winnay JN, Garcia-Martin R, Grinspoon SK Gorder P, Kahn CR. Adipose-Derived Circulating miRNAs Regulate Gene Expression in Other Tissues. 2017;542(7642):450-455. Citações em MyCitations: 285
  • Ferraz RC, Camara H, de Souza EA, Pinto S, Pinca AP, Sato VN, Silva RC, Castilho BA, Mori MA. IMPACT is a Constitutive Inhibitor of GCN2 that Limits Lifespan in C. elegans. BMC Biology. 2016 Oct 7;14(1):87. Citações em MyCitations: 8
  • Reis FC, Branquinho JL, Brandão BB, Guerra BA, Silva ID, Frontini A, Thomou T, Sartini L, Cinti S, Kahn CR, Festuccia WT, Kowaltowski AJ, Mori MA. Fat-specific Dicer Deficiency Accelerates Aging and Mitigates Several Effects of Dietary Restriction in Mice. Aging-US. 2016; 8(5): Online. Citações em MyCitations: 19
  • Oliverio M, Schmidt E, Mauer J, Baitzel C, Hansmeier N, Khani S, Konieczka S, Pradas-Juni M, Brodesser S, Van TM, Bartsch D, Brönneke HS, Heine M, Hilpert H, Tarcitano E, Garinis GA, Frommolt P, Heeren J, Mori MA, Brüning JC, Kornfeld JW. Dicer1-miR-328-Bace1 signalling controls brown adipose tissue differentiation and function. Nat Cell Biol. 2016 Mar;18(3):328-36. Citações em MyCitations: 42
  • Mori MA, Thomou T, Boucher J, Lee KY, Lallukka S, Kim JK, Torriani M, Yki-Järvinen H, Grinspoon SK, Cypess AM, Kahn CR. Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. J Clin Invest. 2014 Aug 1;124(8):3339-51. Citações em MyCitations: 77
  • Cypess AM, White AP, Vernochet C, Schulz TJ, Xue R, Sass CA, Huang TL, Roberts-Toler C, Weiner LS, Sze C, Chacko AT, Deschamps LN, Herder LM, Truchan N, Glasgow AL, Holman AR, Gavrila A, Hasselgren PO, Mori MA, Molla M, Tseng YH. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med. 2013 May;19(5):635-9. Citações em MyCitations: 457
  • Lee KY, Russell SJ, Ussar S, Boucher J, Vernochet C, Mori MA, Smyth G, Rourk M, Cederquist C, Rosen ED, Kahn BB, Kahn CR. Lessons on conditional gene targeting in mouse adipose tissue. Diabetes. 2013 Mar;62(3):864-74. Citações em MyCitations: 214
  • Mori MA, Raghavan P, Thomou T, Boucher J, Robida-Stubbs S, Macotela Y, Russell SJ, Kirkland JL, Blackwell TK, Kahn CR. Role of microRNA processing in adipose tissue in stress defense and longevity. Cell Metab. 2012 Sep 5;16(3):336-47. Citações em MyCitations: 142
Para entrar em contato com Marcelo Alves da Silva Mori e seu laboratório utilize as informações a seguir:
Instituto de Biologia – UNICAMP
R. Monteiro Lobato, 255 - Barão Geraldo
Campinas - SP, 13083-862. Block E, first floor, room 10.
+55 (19) 3521-6232.